Percentage difference is a symmetric way to describe how far apart two numbers are without deciding which one is the official baseline. Scientists comparing instrument readings, shoppers comparing unit prices at two stores, and analysts sanity-checking duplicate data sources all reach for this pattern when chronological order does not matter.
Contrast with percentage change, which is directional: old first, new second. If your problem has a timeline, change is usually clearer. If your problem is “how far apart are A and B?” keep reading.
Engineers sometimes report “relative percent error” between a measured value and a reference standard—same spirit as difference, but always confirm whether the denominator is the average, the reference, or the reading itself.
When A and B carry different orders of magnitude (0.8 vs 800), percent difference can look scary even if the absolute gap is irrelevant—pair numbers with context whenever you present to executives.